The respiratory microbiome in pulmonary tuberculosis: a meta-analysis reveals niche-specific microbial and functional signatures
InfectologiaResumo original em inglês
O que aconteceu
Pulmonary tuberculosis (PTB) remains a leading cause of global mortality, yet the ecological principles shaping its respiratory microbiome are poorly understood. By integrating 16S rRNA datasets from upper and lower airway specimens, this study provides the first comprehensive meta-analysis of respiratory microbial diversity and function in PTB. We reveal distinct community structures and functional potentials among upper airways, sputum, and bronchoalveolar lavage fluid, driven by niche-specific ecological processes rather than stochastic assembly. These findings establish a baseline framework for interpreting microbial biogeography across the respiratory tract and highlight potential microbial biomarkers for site-specific monitoring and therapeutic targeting in PTB.
Resumo publicado sob licença CC BY. A tradução para o português ainda não chegou a este estudo.
O estudo original
The respiratory microbiome in pulmonary tuberculosis: a meta-analysis reveals niche-specific microbial and functional signatures
Mingyang Qin, Yanhua Wen, Shanshan Li, Song Li, Xuming Li, Yuting Lin, Long Hu, Han Xia, Yu Pang, Liang Li
Descritores MeSH
- Bacteria
- Respiratory System
- Tuberculosis, Pulmonary
- Microbiota
- RNA, Ribosomal, 16S
- Bronchoalveolar Lavage Fluid
- Humans
- Sputum
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