Risk factors for invasive mould infections in adult patients with hematological malignancies and/or stem cell transplant: A systematic literature review and meta-analysis

Resumo original em inglês

O que aconteceu

To evaluate risk factors for invasive mould infections (IMI) in adult patients with hematological malignancies and/or hematopoietic stem cell transplantation (HSCT).

Systematic review from PubMed, Embase, CENTRAL, and grey literature (01/01/2002-23/01/2025). Eligible studies were cohort or case-control studies. Selection, data extraction, and bias assessment were performed in duplicate. Adjusted measure effects were pooled using random-effects models.

PROSPERO, CRD42023429103.

O que encontraram

From 13,372 references, 45 studies were included; 17 focused on any type of IMI (n=846), 26 specifically on invasive aspergillosis (IA, n=2086) and 2 on mucormycosis (n=53). Twenty-eight studies (10 on IMI, 18 on IA) were eligible for meta-analysis. Relapsed/refractory hemopathies were significantly associated with a higher risk of IMI (HR 3.43 [95%CI 1.58-7.46]) whereas prolonged neutropenia was associated with IA (OR 4.85 [95%CI 2.15-10.97]). Specifically in the allo-HSCT population, both acute and chronic graft vs host disease (GvHD) (acute GvHD HR 3.23 [95%CI 2.20-4.74]; chronic GvHD HR 2.95 [95%CI 1.25-6.96]) were associated with IMI and CMV disease (HR 3.23 [95%CI 1.00-10.43]), and corticosteroid use (HR 4.67 [95% CI 2.79-7.82]) were associated with IA.

Por que isso importa

Recognizing risk factors for IMI in patients with hematological malignancy or HSCT is essential to improve prevention and management strategies.

Resumo publicado sob licença CC BY. A tradução para o português ainda não chegou a este estudo.