Randomised Controlled Trial on the Additive Effect Between Calcium Hydroxide and Sodium Hypochlorite in an Inter-Visit Root Canal Dressing

Resumo original em inglês

O que aconteceu

To assess whether there was an additive antimicrobial effect between calcium hydroxide (Ca(OH)2) and sodium hypochlorite (NaOCl) in an inter-visit root canal dressing.

Patients presenting with a single-rooted tooth with pulpal necrosis and asymptomatic apical periodontitis were included in this randomised controlled single-center clinical superiority trial with two parallel arms. Teeth were instrumented using a rotary file system and irrigated with 3% NaOCl. Subsequently, the root canals were dressed with a Ca(OH)2 slurry that was prepared from pure Ca(OH)2 powder mixed with either 3% NaOCl (test group) or physiological saline solution (control group). Microbial samples were obtained after accessing the root canal, after chemo-mechanical preparation, and after the root canal dressing with the test or control slurries. A periapical fluid sample was collected after the root canal dressing removal. Samples were transferred to the microbiology lab immediately and assessed for anaerobic growth. The levels of MMP-9 were measured using a specific enzyme-linked immunosorbent assay. Negative to positive growth ratios were compared between groups using Fisher's exact test. Colony-forming units (CFUs) between and within groups and MMP-9/total protein were compared using non-parametric tests, p < 0.05.

CTRI/2020/10/028484 (Clinical Trials Registry India).

O que encontraram

From the 110 patients recruited for this study, 48 were available for all three sampling procedures in the test (NaOCl) and 50 in the control (saline) group. All canals showed anaerobic growth initially. Chemo-mechanical instrumentation significantly reduced CFU counts (p 0.05).

Por que isso importa

Placing a combined NaOCl/Ca(OH)2 dressing significantly reduced the microbial load in the root canals of teeth with primary apical periodontitis compared to a conventional slurry prepared with saline solution, without causing any apparent inflammatory response in the periapical tissues.

Resumo publicado sob licença CC BY. A tradução para o português ainda não chegou a este estudo.