O papel dos fitoquímicos hipoglicemiantes na melhora da disfunção reprodutiva masculina: revisão sistemática de evidências pré-clínicas

Resumo original em inglês

O que aconteceu

The protocol was registered in PROSPERO prior to screening, and PRISMA guidelines 2020 were followed. Papers included in the search were published from October 2010 to October 2025 and were identified using the PubMed, Connecting Repositories, and Google Scholar databases.

The hypoglycemic phytochemicals improved diabetes-induced reproductive dysfunction through their effects on oxidative stress, sperm parameters, spermatogenesis, testicular morphology, testosterone, follicle-stimulating hormone, and luteinizing hormone. There were variations in the outcomes measured and methodologies. The majority of hypoglycemic phytochemicals reduced reactive oxygen species, which may be inadequate in humans, where there is also a psychological impact on erection.

https://www.crd.york.ac.uk/PROSPERO/view/CRD420251230781, identifier CRD420251230781.

O que encontraram

Only 35 studies published between 2012 and 2025 that investigated improvements in male reproductive dysfunction in preclinical settings were reviewed.

Por que isso importa

The review showed that hypoglycemic phytochemicals have the potential to improve male reproductive dysfunction in preclinical models of diabetes mellitus. The synthesis highlights the beneficial effects on glycemic control, sperm quality, hormonal regulation, oxidative stress, and testicular histology via integrated metabolic and reproductive mechanisms. Standardized phytochemicals should be used to study efficacy and safety before clinical trials.

Resumo publicado sob licença CC BY. A tradução para o português ainda não chegou a este estudo.