Melatonin effects on the left ventricular function in neonates with persistent pulmonary hypertension
PediatriaResumo original em inglês
O que aconteceu
registered on ClinicalTrials.gov (ID: NCT07090720), URL: https://clinicaltrials.gov/study/NCT07090720?cond=NCT07090720&rank=1 , Date: (29/7/2025).
• PPHN induces hypoxic respiratory failure, jeopardizing multiorgan function, including LV performance. • Oxidative stress is crucial in pulmonary arterial hypertension development.
O que encontraram
• Melatonin's antioxidant and vasodilatory properties may serve as an adjunctive therapy in PPHN and enhance myocardial protection from the hypoxic effect of PPHN.
Por que isso importa
Melatonin can enhance LV function in PPHN, likely through its cardioprotective and antioxidative mechanisms. These findings support melatonin as a promising adjunctive therapy in neonatal pulmonary hypertension, warranting further investigation in larger clinical trials.
Resumo publicado sob licença CC BY. A tradução para o português ainda não chegou a este estudo.
O estudo original
Melatonin effects on the left ventricular function in neonates with persistent pulmonary hypertension
Sarah M Nofal, Abdel-Rahman M El-Mashad, Asmaa Mahmoud Elmesiry, Amany M Abouelenain, Mostafa M Awny
Descritores MeSH
- Antioxidants
- Melatonin
- Persistent Fetal Circulation Syndrome
- Ventricular Function, Left
- Infant, Newborn
- Male
- Treatment Outcome
- Oxidative Stress
- Biomarkers
- Natriuretic Peptide, Brain