Mais do que Hormones? Efeitos Metabólicos da Suplementação Probiótica de Doze Semanas em Mulheres com Síndrome do Ovário Policístico: Uma Análise Secundária de um Estudo Controlado com Placebo Duplo, Aleatório

Resumo original em inglês

O que aconteceu

Polycystic ovary syndrome (PCOS) is frequently associated with insulin resistance and dyslipidemia. Evidence regarding the metabolic effects of probiotics in PCOS remains inconsistent. This secondary analysis evaluated whether multispecies probiotic supplementation influenced glucose homeostasis, insulin resistance, and the lipid profile in women with PCOS.

Data were derived from a 12-week randomized, double-blind, placebo-controlled study in which 50 women with PCOS were assigned to receive either a nine-strain probiotic (1.0 × 10 9 CFU/day) or placebo. Fasting and 120 min glucose and insulin concentrations, HOMA-IR, total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides were assessed at baseline and follow-up. Treatment effects were evaluated using analysis of covariance adjusted for baseline values. The main analysis was based on participants with available follow-up data, and an intention-to-treat sensitivity analysis including all 50 randomized participants was performed using multiple imputation for missing follow-up measurements.

O que encontraram

Forty-three participants were included in the complete-case analysis (probiotic, n = 19; placebo, n = 24); seven did not complete follow-up (six in the probiotic group, one in the placebo group). No statistically significant between-group differences were detected for glucose homeostasis, HOMA-IR, or lipid profile. The intention-to-treat sensitivity analysis yielded findings consistent with the complete-case analysis.

Por que isso importa

Twelve weeks of multispecies probiotic supplementation did not result in statistically significant improvements in glucose metabolism, insulin resistance, or lipid profile compared with placebo. Given the relatively small sample size and limited precision of some estimates, clinically relevant effects cannot be excluded. Larger randomized controlled trials are warranted.

Resumo publicado sob licença CC BY. A tradução para o português ainda não chegou a este estudo.