Fertility-Related Concerns in Survivors of Childhood Cancer: A Systematic Review

Resumo original em inglês

O que aconteceu

Childhood cancer survivors are at increased risk for treatment-related fertility impairment and subsequent fertility-related concerns. However, there is currently no consensus on how to define, assess, and address these concerns in clinical practice. Therefore, we aimed to answer the following questions: (1) How are fertility-related concerns assessed and defined? (2) What types of fertility-related concerns are reported by survivors, and how common are they? (3) What clinical implications are proposed in the literature?

We systematically searched the databases PubMed, PsycINFO, MEDLINE, CINAHL, and Embase for peer-reviewed publications on fertility-related concerns in survivors of childhood cancer published between January 1990 and November 2023. The search yielded 2077 potentially relevant articles, of which eleven met inclusion criteria and were included. Furthermore, we screened the reference lists of included studies, leading to a total of N = 25 studies included in the narrative synthesis.

O que encontraram

We identified considerable variation in the assessment, description, and definition of fertility-related concerns. Survivors described fertility-related concerns in terms of their personal and reproductive health, the health of their (future) children, and dating and romantic relationships. Concerns were reported by 9.5% to 65% of survivors in quantitative studies. Suggestions for clinical implications included that different healthcare providers could use individual or group strategies to address fertility-related concerns. They should focus on patient reports rather than parent-proxy reports and assess individual fertility-related preferences and attitudes without making assumptions.

Por que isso importa

Fertility-related concerns are common among childhood cancer survivors and need to be addressed by care providers and researchers in the field. To do so effectively, we need more consistency in assessing, labeling, and defining these concerns.

Resumo publicado sob licença CC BY. A tradução para o português ainda não chegou a este estudo.