Evidência aleatória direta comparando ranibizumab e bevacizumab para edema macular secundário à oclusão da veia retiniana: revisão sistemática e metanálise

Resumo original em inglês

O que aconteceu

Intravitreal anti-vascular endothelial growth factor therapy is the first-line treatment for macular edema secondary to retinal vein occlusion. However, direct comparative evidence between ranibizumab and bevacizumab from randomized controlled trials remains limited. This study aimed to compare the efficacy and safety of these two agents using evidence from randomized controlled trials.

We systematically searched PubMed, Embase, the Cochrane Library, and Web of Science from database inception to February 11, 2026. Eligible studies were published randomized controlled trials directly comparing intravitreal ranibizumab and bevacizumab monotherapy in adults with RVO-ME. Nonrandomized and noncomparative studies were excluded.

Not applicable.

PROSPERO CRD420251172336.

O que encontraram

Four randomized controlled trials involving 759 participants were included. At 6 months, no significant difference was observed in mean best-corrected visual acuity (BCVA) change (MD 0.61 letters, 95% CI -1.95 to 3.18). The pooled mean difference in central macular thickness (CMT) change was 1.52 μm (95% CI -237.41 to 240.46). The proportion of eyes gaining ≥ 15 ETDRS letters was comparable (RR 0.97, 95% CI 0.82 to 1.14). Safety profiles were broadly similar. Rare systemic events were infrequent and associated with considerable statistical uncertainty. Certainty of evidence was moderate for visual outcomes and low to very low for rare adverse events.

Por que isso importa

Ranibizumab and bevacizumab show comparable short-term efficacy and safety for macular edema secondary to retinal vein occlusion, although evidence for rare systemic events remains uncertain.

Resumo publicado sob licença CC BY. A tradução para o português ainda não chegou a este estudo.