Estimulação contínua de teta cerebelar para transtorno de insônia: um ensaio controlado por Sham aleatório

Resumo original em inglês

O que aconteceu

To evaluate the effects of cerebellar continuous theta burst stimulation (cTBS) in insomnia disorder (ID)

In this randomized sham‐controlled trial, patients with ID received 2 weeks of active or sham cerebellar cTBS. The primary outcome was a ≥ 3‐point improvement in Pittsburgh Sleep Quality Index (PSQI) score after treatment. Secondary outcomes included changes in sleep, mood, and resting‐state fMRI

ClinicalTrials.gov (NCT05992285)

O que encontraram

Seventy‐two patients (51 women; mean age, 44.3 ± 11.6 years) were included in the intention‐to‐treat analysis. More patients in the active than sham group achieved a ≥ 3‐point PSQI improvement after treatment (75.0% vs. 33.3%; adjusted OR, 6.06; 95% CI, 2.17–18.50; p < 0.001). Active cTBS reduced PSQI scores versus sham both post‐treatment (adjusted mean difference, −3.34; 95% CI, −4.57 to −2.12; p < 0.001) and at 1 month (−3.70; 95% CI, −4.93 to −2.48; p < 0.001), and also improved Insomnia Severity Index, Hamilton Anxiety Scale, and Hamilton Depression Scale at both time points (all p < 0.01). Exploratory fMRI analyses identified several post‐treatment connectivity differences between groups, but only right amygdala–right orbitofrontal connectivity showed a significant group‐by‐time interaction (FDR‐adjusted p = 0.038). No serious adverse events occurred

Por que isso importa

Cerebellar cTBS was well tolerated and promising for ID

Resumo publicado sob licença CC BY. A tradução para o português ainda não chegou a este estudo.