Eficácia de um suplemento de cranberry padronizado em sintomas hiperativos da bexiga e alterações do urobiome em mulheres jovens: um ensaio piloto randomizado, duplo-cego, controlado por placebo

Resumo original em inglês

O que aconteceu

Urobiome dysbiosis has been implicated in the pathogenesis of overactive bladder (OAB). In this study, the efficacy of a cranberry supplement for OAB symptoms was investigated, and concurrent urobiome alterations were evaluated in young women.

This double-blind, randomized, placebo-controlled trial enrolled 26 women (median age, 23 years) with OAB (Overactive Bladder Symptom Score [OABSS] ≥ 3), who received either a cranberry supplement (36 mg proanthocyanidins per day) or placebo for 4 weeks. Clinical efficacy was assessed using the OABSS reduction rate, and urobiome composition was evaluated by 16S rRNA gene sequencing.

https://www.umin.ac.jp/ctr/, identifier UMIN000057544.

O que encontraram

Twenty-five participants were included in the analysis. At 4 weeks, the OABSS reduction rate was greater in the cranberry group than in the placebo group (median, 66.7% vs. 40.0%; p = 0.039). At baseline, the urobiome was dominated by Lactobacillus (median relative abundance, 64.2%). After cranberry supplementation, the relative abundance of Lactobacillus decreased within the cranberry group (median change, -4.39%; p = 0.027; q = 0.096). No compositional changes were observed in the placebo group.

Por que isso importa

Cranberry supplementation was associated with greater improvement in OAB symptoms than was observed with placebo in young women, while a decrease in Lactobacillus relative abundance was observed within the cranberry group. Given the small sample size of this exploratory pilot trial and the limited species-level resolution of 16S rRNA sequencing, these concurrent findings should be regarded as hypothesis-generating and warrant further investigation.

Resumo publicado sob licença CC BY. A tradução para o português ainda não chegou a este estudo.