Efeitos do treinamento de força muscular com restrição do fluxo sanguíneo sobre a função glomerular em pessoas com doença renal crônica estágio 3

Resumo original em inglês

O que aconteceu

Stage 3 chronic kidney disease (CKD) represents a critical juncture in clinical management. However, muscle strength training (MST) combined with blood flow restriction (BFR) has shown benefits as an adjunctive treatment, but its renal effects remain unclear.

To analyze the effects of MST+BFR on markers of glomerular function in individuals with CKD-3.

A randomized, longitudinal clinical trial with 40 participants divided into 4 groups: control (G1); low-load MST (G2); high-load MST (G3); and low-load MST combined with BFR (G4). Serum creatinine, cystatin C, microalbuminuria, and estimated eGFR were used as dependent variables. The MST protocol was conducted over 12 weeks, 3 times per week, for 30-40 minutes, with 3 exercises (single- and multi-joint) per day at progressive intensities. Data analysis (intention-to-treat) was performed using the Shapiro-Wilk test (normality), paired t-test/Wilcoxon test (within-group comparisons), ANOVA/Kruskal-Wallis tests (between-group comparisons), Bonferroni test (post hoc corrections), and Cohen's d (effect size) with a p-value ≤ 0.05.

O que encontraram

The participants were predominantly male (52.5%) with low levels of physical activity (60%), hypertension (87.5%), and some with diabetes (37.5%). Group 4 showed a significant increase in albuminuria levels (p = 0.048), as well as significant differences compared with Group 1 (creatinine, p = 0.032) and Group 2 (creatinine, p = 0.036; and eGFR-Cr, p = 0.032).

Por que isso importa

MST+BFR was not associated with severe adverse effects on serum creatinine/cystatin C levels, eGFR estimates, or urinary creatinine and microalbuminuria levels, but it may significantly increase albuminuria levels.

Resumo publicado sob licença CC BY. A tradução para o português ainda não chegou a este estudo.