Efeitos da suplementação de vitamina C e/ou E no Controle Glicêmico e Fatores de Risco Cardiovascular em Diabetes Tipo 2: Revisão Sistemática e Meta-análise Subgrupo

O que aconteceu

Type 2 diabetes (T2D) is one of the fastest-growing global health emergencies of the 21st century. However, high antioxidant capacity of supplementation of vitamin C and/or E was inversely associated with insulin resistance. However, each antioxidant possesses a distinct biological function that may be influenced by both dosage and duration of supplementation, potentially resulting in significantly different effects. This meta-analysis aimed to evaluate whether vitamin C, vitamin E, or their combination is more effective in improving glycemic control, blood lipids, and blood pressure in individuals with T2D. A systematic search was conducted in PubMed, Scopus, and Web of Science databases for randomized clinical trials, identifying 52 studies (n = 1425 participants). Random-effects models were used to assess the effects of vitamin C and/or E supplementation on glycemic control, blood lipid levels, and blood pressure. These findings indicate that supplementation with vitamin C, vitamin E, or their combination has a comparable effect on glycemic index values, systolic blood pressure, and blood lipid profiles. However, a significant reduction in systolic blood pressure was observed only with vitamin C and combined vitamin C + E supplementation. Additionally, a significant increase in high-density-lipoprotein (HDL) levels was noted exclusively with the combined vitamin C + E supplementation.

Trecho mantido em inglês: a tradução automática não passou na conferência de números.

O que encontraram

CRD42023399366.

Por que isso importa

Consequentemente, a suplementação com vitamina C, vitamina E e sua combinação (C + E) apresentaram diferentes efeitos nos níveis de HDL e pressão arterial sistólica. No entanto, seus efeitos sobre o controle glicêmico, pressão arterial diastólica e outros lipídios sanguíneos além do HDL foram comparáveis.