Efeito da suplementação de vitamina D nos desfechos clínicos de pacientes com doença de Parkinson: Estudo randomizado controlado

Resumo original em inglês

O que aconteceu

Vitamin D deficiency is linked to Parkinson disease (PD) pathogenesis; however, clinical trial results remain inconclusive. Thus, in this study, we aimed to evaluate the prevalence of vitamin D deficiency in Thai patients with PD and the efficacy of vitamin D3 supplementation on clinical outcomes in a tropical, sun-abundant region.

In this randomized controlled trial, we enrolled 60 patients with PD and 60 healthy controls. Patients with PD were randomized 1:1 to receive 2000 IU/d of vitamin D3 or no additional treatment (control) for 12 weeks. Primary outcomes included changes in MDS-UPDRS, Hoehn and Yahr (mH&Y), Thai Mini-Mental State Examination, and PDQ-39 scores. The secondary outcome was the prevalence of vitamin D deficiency (25(OH)D < 20 ng/mL).

O que encontraram

At baseline, vitamin D deficiency was significantly more prevalent in patients with PD than in healthy controls (23.2% vs 10.0%, P = .046). After 12 weeks, the vitamin D group showed a significant increase in serum 25(OH)D levels compared to the control group (P < .001, successfully normalizing levels in the deficiency subgroup (30.96 ± 3.18 ng/mL). Although Thai Mini-Mental State Examination scores improved significantly within the vitamin D group (mean difference 1.37, P < .001), a similar improvement occurred in the control group (mean difference 0.93, P = .010), with no significant difference between groups (P = .378). No significant improvements were observed in motor function (MDS-UPDRS, mH&Y) or quality of life (PDQ-39).

Por que isso importa

Vitamin D deficiency is common among Thai patients with PD, despite equatorial proximity. While 2000 IU/d of vitamin D3 safely corrected nutritional deficiency, it provided no significant short-term motor or cognitive benefits.

Resumo publicado sob licença CC BY. A tradução para o português ainda não chegou a este estudo.