Desempenho Diagnóstico Comparativo de Tomografia Computada de Viga de Cone e Absorciometria de Raio-X de dupla energia para Avaliação de Baixa Densidade Óssea. Revisão sistemática e meta-análise

Resumo original em inglês

O que aconteceu

This systematic review evaluated the diagnostic accuracy of CBCT for BMD assessment using DEXA as the reference standard and aimed to quantify its performance through meta-analysis.

This review included prospective and retrospective observational studies assessing CBCT's diagnostic performance in detecting low BMD, with DEXA as the reference. Searches in PubMed, Embase, and Scopus identified 13 eligible studies involving adult participants (≥ 18 years). Two reviewers independently extracted data and assessed study quality using the QUADAS-2 tool. Meta-analysis was conducted using random-effects models.

O que encontraram

Pooled sensitivity and specificity of CBCT for detecting low BMD were 0.58 (95% CI: 0.50-0.67) and 0.78 (95% CI: 0.69-0.86), respectively. The summary receiver operating characteristic (SROC) curve showed an area under the curve (AUC) of 0.73 (95% CI: 0.69-0.77), indicating moderate diagnostic accuracy. Subgroup analyses revealed heterogeneity influenced by sample size and anatomical site.

Por que isso importa

CBCT demonstrates moderate diagnostic accuracy in detecting low BMD, with better specificity than sensitivity. While promising, standardization of CBCT protocols and larger studies are needed to confirm its role in clinical assessment. PROSPERO REGISTRATION NUMBER: (CRD42024598958).

Resumo publicado sob licença CC BY. A tradução para o português ainda não chegou a este estudo.