CPAP inicial de 5 versus 8 cmH2O durante a estabilização da sala de parto de lactentes muito prematuros: o ensaio-piloto de PHILODENDROOM randomizado

Resumo original em inglês

O que aconteceu

• CPAP is a cornerstone of respiratory support for very preterm infants in the DR, but the optimal initial distending pressure remains uncertain. • Higher CPAP levels may improve lung recruitment, although concerns persist regarding air leaks and potential harm.

O que encontraram

• In this pilot trial, both 5 and 8 cmH2O initial CPAP levels were feasible and safe during DR stabilisation of very preterm infants. • Higher initial CPAP was associated with delayed surfactant threshold achievement, highlighting the potential role of additional tools such as lung ultrasound to tailor and guide individualised respiratory support.

Por que isso importa

This pilot randomised trial demonstrated that comparing two initial CPAP strategies during DR stabilisation of very preterm infants is feasible and no significant adverse events have been reported. While higher initial CPAP was associated with delayed achievement of the FiO2 threshold for surfactant administration, exploratory physiological and clinical findings should be considered hypothesis-generating. Adequately powered multicentre trials incorporating physiological bedside assessment of lung aeration are needed to determine the optimal initial CPAP strategy during neonatal transition.

Resumo publicado sob licença CC BY. A tradução para o português ainda não chegou a este estudo.